We develop flexible IoT gateway that can adopt different commercial product for measuring. In such a way different users/patients owing products can use this solution. Platform is not restricted to only specific vendors. In personalized healthcare monitoring, wearable are playing in important role in terms of data measurement collection. Hence we develop an innovative wrist-worn prototype for ambient monitoring and flexible IoT gateway. The prototype measures the most critical parameter from an ambient domain. Therefore depending on the target investigation, status of the patients, requirements and demands, medics can determine the setup parameter for measurements. Thus the application of this platform is not limited to specific groups but widely may be applied whether in daily routine or medical research investigation.