In this comprehensive monograph, we explore the dynamic field of cancer immunotherapy, delving into its groundbreaking principles, pivotal clinical trials, and transformative success stories. From the elucidation of immune checkpoints to the revolutionary CAR-T cell therapies, this monograph highlights the profound impact of immunotherapy on various cancer types. With in-depth analyses of immune-related adverse events, resistance mechanisms, and emerging trends, this publication offers a compelling perspective on the current and future trajectory of cancer treatment.