Removable complete denture is one of the most common treatment modalities for completely edentulous patients. The overall success of complete denture therapy depends on patient’s comfort and acceptance of the dentures. Even though complete care is taken during fabrication procedures, there is still a wide spectrum of problems associated with denture placement and dental literature is replete with such issues and problems faced by patients, consequent to denture insertion. If these complaints are not addressed properly it will lead to patient disappointment and ultimately removable dental prostheses failure. A careful analysis based on a thorough understanding of usual and unusual tissue response as well as of the basic principles of complete denture prosthesis is also crucial in eliminating such problems associated with complete denture use. The follow-up care of complete denture is thus an important and critical phase in the treatment of the edentulous patient and can uncover minor or major problems and complaints which will be helpful in ensuring a good clinical outcome.