Recently, the complexion of curcumin - N-heterocyclic with metal ions has attracted the attention of researchers around the world as one of the user requirements for the treatment of Alzheimer’s disease and in vitro antioxidant activity. Curcumin and its derived have been used in many fields such as traditional medicine, food additive, dye, indicator. Many studies indicate that curcumin is a potent anticancer agent Scheme of the oral cavity, skin, mammary gland, forestomach, N-heterocyclic and its derivatives exhibit a wide range of medicine - biological applications.