curcumin complexes as a polyphenolic species. Its traditional medicinal propertiesbesides affecting several biological pathways to arrest tumor growth and its progression. The book has shown that curcumin -metal-bound form retains its therapeutic potential. (CUM )-based M(II) complexes as anticancer agents act as a reducing agent. find application in biology and drug in medicine, diagnosis and cancer treatment acts as a reducing agent metal –Curcumin nanoparticles