Oxidative stress is defined as an imbalance between productions of free radicals and reactive metabolites. This imbalance leads to damage of important biomolecules and cells, with potential impact on the whole organism. There is currently arenewed interest in phytochemicals as sources of natural antioxidants.In this book, we tested in vivo the antioxidant and anti-inflammatory effect of the grape Leaves Vitis vinifera Algerian Variety on the cardiovascular inflammation induced by Hyperhomocysteinemia.Also, we conducted a study in vitro to analyze the total phenols, anti-oxidative, anti-proliferative properties on MCF-7 and HepG2 Human Cancer CellLines and on modulate of Apoptosis-Related Gene Expression of water and ethanol crude extracts obtained by Accelerator Solvent Extractor from grape leaves (Vitis vinifera) grown in Algeria.