This book aims to provide a perspective on factors that mostly influence business performance. The focus of this study is theoretical and practical oriented on tourism SMEs management. Addressing the relationships between innovation, human resources practices, customer orientation and their interplay effects on performance, undoubtedly contribute to the actual and future researches on the strategic management field. Investigating the issues of how SMEs achieve high performance has significant implications for SMEs' managers. In this framework, decision-makers on management level will have a value-added for their daily management and a clear view on what to pay more attention referring to their business’ environment. Additionally, results are also in terms of regional economic development, as well. SMEs generate societal growth in terms of revenues and new jobs and as a result the well-being of people living in the area.