The current study included fifty-six young male albino rats (4 months old and weighted 280 –290 gm), and twenty-four senescent male albino rats (24 months old and weighted 420 – 450 gm). The study was conducted in Biology Department of the College of Science, University of Mosul, and in the Medical Research Center of Hawler Medical University. Animals' treatment and assessing biomarkers of the experiment lasted a period between January- 2013 and December - 2014. The present study aimed to investigate the antiaging properties of grape seed extract (GSE), green tea extract (GTE), pomegranate seed extract (PSE), ginkgo biloba extract (GBE), α- lipoic acid (LA) and centrophenoxine (CPH) in normal and D- galactose (D-gal) induced aged male albino rats, and their preventing and improving effects in some biomolecular and physiological biomarkers of aging resulted from oxidative damage to cells in natural and D-gal induced aged rats.