Hebeish’s work has been the subject of more than 580 papers that have been carried out and published during the last Five decades. The work addresses many basic and practical aspects of chemical modification of fibrous textile polymers and their properties as well as the fundamentals and practices pertaining to synthesis, characterization and application of various nonfibrous textile auxiliaries. Nature of textile substrates for example cotton textile could be changed through introducing, in its macromolecular structure, different amounts of chemical groups in the monomeric and /or polymeric forms. Similarly, nature of the newly synthesized nonfibrous polymeric textile auxiliaries could be modulated (tailored) through manipulation of the molecular weight of the parent (base) polymer along with type, form and amount of the introduced chemical moieties. This indeed, stimulates research which was targeted towards production of multifunctional cotton products (often called smart textile or high performance textile products) through harnessing nanotechnology and biotechnology in multifinishing process.