The Time Gene

Behcet's disease is characterized by recurrent oral ulcers, uveitis, oral ulcers, and skin lesions. Since vascular manifestations are common in this disease, it is considered as vasculitis. However, the dominant histological pathological symptoms in inflamed tissues include infiltration of lymphocytes, monocytes and in some cases, polynuclear leukocytes. Although small vessels are visible without microscopic changes in the wall. Thrombophilia or coagulation in small and large vessels is common, while arthritis is rare in this disease. In this regard, Behcet's disease is unique compared to other vasculitis. This disease is more prevalent in the countries along the Silk Road from Japan to the Mediterranean regions, so it prompted us to prioritize this disease in our studies. BCL2 and BAX genes are a group of signaling inducing and inhibiting genes that play a key role in the process of physiological cell death (apoptosis).