Therapeutic Role of Two Medicinal Plants against CCl4 in Rats

The book will assess the potential role of two medicinal plant (Plantago major and Moringa oleifera) against CCl4-induced hepatotoxicity in rats. The SOD like activity of the Plantago major and Moringa oleifera extract was performed in Vitro. Some biochemical markers such as alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), albumin, total protein, cholesterol, triglycerides and total lipids in serum were investigated. Also, hematological tests including RBCs and WBCs count, hemoglobin level and hematocrit percentage were also investigated. In addition to antioxidant biomarkers such as catalase (CAT), superoxide dismutase (SOD), total antioxidant capacity (TAC), reduced glutathione (GSH) and the level of lipid peroxidation (malondialdehyde, MDA), along with histopathological examination were determined. Results of the present study showed that, CCl4 induced a significant reductions in the total body weights of the intoxicated rats and significant increase in liver-body weight ratio when compared with the control olive oil group. Moreover, Plantago major and Moringa oleifera leaves extract could improve the hepatomegaly induced by chronic CCl4 adm