SPECTROPHOTOMETRIC AND SPECTROSCOPIC STUDIES OF NOVEL ANTI-CANCER DRUG

Understanding the charge transfer process between bioactive molecules and inorganic or organic molecules is significant as this interaction can be used to interpret bioactive molecule–receptor interactions. A comprehensive spectrophotometric study has been performed to explore the complexation chemistry of the Crizotinib (CZT) with π - acceptor. The molecular structure, spectroscopic characteristics and the interactive modes have been deduced from UV–Vis and FT-IR spectra. The binding ratio of complexation has been determined to be 1:1 for acceptor with CZT. Benesi–Hildebrand method was applied to estimate the spectroscopic and physical data. The association constant (K), extinction coefficient (εmax), ionization potential (IP), energy of the charge transfer complex (ECT), resonance energy (RN), dissociation energy (W) and standard Gibbs energy ( G0) have been computed. Based upon the obtained spectroscopic data, the plausible CT mechanism between CZT and acceptor was proposed.